Anti-CD61 Monoclonal Antibody (Clone:VIPL2)-FITC Conjugated

Product code: 30-2067

Clone name : VIPL2
Clonality : Monoclonal
Application : FACS, WB, IHC-Fr
Reactivity : Human, Non-Human Primates
Conjugate : FITC

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100 tests
$433.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : ITGB3
Gene ID : 3690
Uniprot ID : P05106
Alternative Name : ITGB3, GP3A
CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
Subcellular location: Cell membrane, Cell projection, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
BioGrid: 109896. 41 interactions.
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