Anti-CD61 Monoclonal Antibody (Clone:VIPL2)-PE Conjugated
Figure 1: Surface staining of human peripheral blood with anti-human CD61 (VIPL2) PE.
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
Amount : | 100 tests |
Isotype : | Mouse IgG1 |
Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
Subcellular location: | Cell membrane, Cell projection, Cell junction |
Post transnational modification: | Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. |
Tissue Specificity: | Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis. |
BioGrid: | 109896. 41 interactions. |
There are currently no product reviews
|