Anti-CD59 / Protectin Monoclonal Antibody (Clone:MEM-43)-APC Conjugated

Product code: 30-1699

Clone name : MEM-43
Clonality : Monoclonal
Application : FACS, IP, IHC
Reactivity : Human
Conjugate : APC

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG2a
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD59
Gene ID : 966
Uniprot ID : P13987
Alternative Name : CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Immunogen Information : Thymocytes and T lymphocytes
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Subcellular location: Cell membrane, Secreted
Post transnational modification: Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.
BioGrid: 107404. 37 interactions.
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