Anti-CD59 / Protectin Monoclonal Antibody (Clone:MEM-43)-Biotin Conjugated
Figure 1: Surface staining of HL-60 (positive) and SP2 (negative) cells with anti-human CD59 (MEM-43) biotin / streptavidin-APC.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2a |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
| Subcellular location: | Cell membrane, Secreted |
| Post transnational modification: | Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes. |
| BioGrid: | 107404. 37 interactions. |
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