Anti-CD54 Monoclonal Antibody (Clone:YN1/1.7.4)-FITC Conjugated(Discontinued)
Figure 1: Surface staining of mouse thymocytes using anti-CD54 monoclonal antibody (clone YN1/1.7.4).
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD54 (ICAM-1) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
| Subcellular location: | Membrane |
| Post transnational modification: | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Tissue Specificity: | Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells. |
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