Anti-CD54 / ICAM-1 Monoclonal Antibody (Clone:MEM-111)

Product code: 30-1133

Clone name : MEM-111
Clonality : Monoclonal
Application : FACS
Reactivity : Rat

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ICAM1
Gene ID : 3383
Uniprot ID : P05362
Alternative Name : ICAM1
Immunogen Information : Raji human Burkitt's lymphoma cell line

CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.

Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml; positive tissue: thymus, RE cells.
Western blotting: Positive control: RAJI cell line K562 leukemia cell line, JY cell line, aa ctivated T-lymphocytes, non-reducing conditions.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
BioGrid: 109610. 178 interactions.
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