Anti-CD54 / ICAM-1 Monoclonal Antibody (Clone:1H4)-Biotin Conjugated
Figure 1: Expression of CD54 in normal human peripheral blood, as detected with anti-CD54 (1H4) biotin.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
| Subcellular location: | Membrane |
| Post transnational modification: | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| BioGrid: | 109610. 178 interactions. |
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