Anti-CD53 Monoclonal Antibody (Clone:MEM-53)-Azide free(Discontinued)
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| Format : | Azide free |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
Flow Cytometry Recommended dilution:4 µg/ml
Immunoprecipitation Western Blotting Immunohistochemistry (frozen sections) It is suitable for discrimination of lymphomas from other tumors. Functional Application The antibody MEM-53 induces activation of monocytes and B lymphocytes.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell junction, Membrane |
| Tissue Specificity: | B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells. |
| BioGrid: | 107401. 26 interactions. |
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