Anti-CD53 Monoclonal Antibody (Clone:MEM-53)-Low Endotoxin(Discontinued)

Product code: 30-1601

Clone name : MEM-53
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD53
Gene ID : 963
Uniprot ID : P19397
Alternative Name : CD53, MOX44, TSPAN25
Immunogen Information : Leukocytes of pacient suffering from a LGL-type leukemia.

CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.

Functional application: The antibody MEM-53 induces activation of monocytes and B lymphocytes. <br>Immunohistochemistry (frozen sections): It is suitable for discrimination of lymphomas from other tumors. <br>Flow cytometry: Recommended dilution: 1-5 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell junction, Membrane
Tissue Specificity: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
BioGrid: 107401. 26 interactions.
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