Anti-CD5 Monoclonal Antibody (Clone:53-7.3)-PE Conjugated

Product code: 30-2368

Clone name : 53-7.3
Clonality : Monoclonal
Application : FACS, IP, IHC, IHC-Fr
Reactivity : Mouse
Conjugate : PE

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Size
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0.1 mg
$380.00 

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Amount : 0.1 mg
Isotype : Rat IgG2a
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : Cd5
Gene ID : 12507
Uniprot ID : P13379
Alternative Name : Cd5, Ly-1
Immunogen Information : mouse thymus or spleen cells
CD5 (T1) is a single-chain transmembrane glycoprotein expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.
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