Anti-CD49d / Integrin alpha 4 Monoclonal Antibody (Clone:9F10)-Low Endotoxin

Product code: 30-1590

Clone name : 9F10
Clonality : Monoclonal
Application : FACS, IHC-Fr, Functional Assay
Reactivity : Human, Non-Human Primates, Bovine, Dog, Equine, Feline, Sheep

Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price
0.1 mg
$389.00 

Add to Wish List

Shipping Info:

For estimated delivery dates, please contact us at [email protected]


Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ITGA4
Gene ID : 3676
Uniprot ID : P13612
Alternative Name : ITGA4, CD49D
CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.

Flow Cytometry Immunohistochemistry (frozen sections) Functional Application in vitro T cell costimulation

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Phosphorylation on Ser-1027 inhibits PXN binding.
BioGrid: 109883. 517 interactions.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products