Anti-CD49b / Integrin alpha 2 Monoclonal Antibody (Clone:AK7)-PE Conjugated

Product code: 30-2126

Clone name : AK7
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, ICC, ELISA
Reactivity : Human, Non-Human Primates
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : ITGA2
Gene ID : 3673
Uniprot ID : P17301
Alternative Name : ITGA2, CD49B
Immunogen Information : Human platelets
CD49b / Integrin alpha 2 (ITGA2; alpha 2 subunit of VLA-2) heterodimerizes with CD29 to form the VLA-2 integrin alpha2/beta1 complex, which serves as a receptor for type I collagen, laminin, and E-cadherin. It also acts as a receptor for echovirus. Expressed on platelets, activated lymphocytes, monocytes, fibroblasts, epitelial and endothelial cells, CD49b mediates adhesion of these cells to the extracellular matrix. This interaction supports e.g. T cell proliferation and cytokine production, or wound healing. Defect in CD49b is associated with bleeding disorder platelet-type 9. Antibodies against CD49b are found in several immune disorders, including neonatal alloimmune thrombocytopenia.
Subcellular location: Membrane
BioGrid: 109880. 31 interactions.
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