Anti-CD47 antibody(DM212), Rabbit mAb
Figure 1. Competition assay demonstrating DM212 blockade of SIRP alpha binding to Jurkat cell line.
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| Amount : | 100 µg |
| Purification : | Purified from cell culture supernatant by affinity chromatography |
| Content : | 100 ug in PBS, lyophilized (Not sterile) Reconstitute in sterile water. |
| Storage condition : | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
| Alternative Name : | CD47, MER6, IAP, OA3 |
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
ELISA 1/5000-10000;FACS 1/100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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