Anti-CD46 / Membrane Cofactor Protein Monoclonal Antibody (Clone:MEM-258)

Product code: 30-1220

Clone name : MEM-258
Clonality : Monoclonal
Application : FACS, IP, WB
Reactivity : Human, Bovine

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD46
Gene ID : 4179
Uniprot ID : P15529
Alternative Name : CD46, MCP, MIC10
Immunogen Information : HPB-ALL human T cell line
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Flow Cytometry Recommended dilution:1 µg/ml
Immunoprecipitation Western Blotting Application note: Non-reducing conditions.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasmic vesicle
Post transnational modification: In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.
Tissue Specificity: Expressed by all cells except erythrocytes.
BioGrid: 110346. 11 interactions.
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