Anti-CD45RA Monoclonal Antibody (Clone:MEM-56)

Product code: 30-1128

Clone name : MEM-56
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : PTPRC
Gene ID : 5788
Uniprot ID : P08575
Alternative Name : Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, CD45
Immunogen Information : Human thymocytes and T lymphocytes.

CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naïve T cells and normal plasma cells.

Immunohistochemistry (paraffin sections): No pre-treatment of tissue sections is needed. <br>Flow cytometry:  Recommended dilution: 0.3-4 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane, Cell membrane
Post transnational modification: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
Tissue Specificity: Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.
BioGrid: 107366. 23 interactions.
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