Anti-CD45R0 Monoclonal Antibody (Clone:UCHL1)

CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.

Flow Cytometry Application note:
Use 10 µl of the suggested working dilution to label 10⁶ cells in 100 µl.
Immunoprecipitation Immunohistochemistry Pretreatment: This product does not require protein digestion pretreatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Positive tissue: tonsil
Immunohistochemistry (frozen sections) Positive tissue: tonsil

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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