Anti-CD45 Monoclonal Antibody (Clone:EM-05)

Product code: 30-1386

Clone name : EM-05
Clonality : Monoclonal
Application : FACS, IP, WB, ICC
Reactivity : Mouse

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0.1 mg
$345.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Rat IgG
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Ptprc
Gene ID : 19264
Uniprot ID : P06800
Alternative Name : Ptprc, Ly-5
Immunogen Information : Murine peripheral blood leukocytes
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

Flow Cytometry Recommended dilution: 2 µg/ml
Positive control: murine peripheral blood leukocytes
Immunoprecipitation Western Blotting Immunocytochemistry

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Membrane raft
Post transnational modification: Heavily N- and O-glycosylated.
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