Anti-CD44 / Pgp-1 Monoclonal Antibody (Clone:MEM-85)-Biotin Conjugated

Product code: 30-1846

Clone name : MEM-85
Clonality : Monoclonal
Application : FACS, IP, WB, ELISA
Reactivity : Human
Conjugate : Biotin

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0.1 mg
$433.00 

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Amount : 0.1 mg
Isotype : Mouse IgG2b
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD44
Gene ID : 960
Uniprot ID : P16070
Alternative Name : CD44, LHR, MDU2, MDU3, MIC4
Immunogen Information : Leukocytes of a patient suffering from LGL Type Leukaemia.
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Subcellular location: Cell membrane, Cell projection
Post transnational modification: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
Tissue Specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
BioGrid: 107398. 132 interactions.
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