Anti-CD44 Monoclonal Antibody (Clone:IM7)(Discontinued)
Figure 1: Western blotting analysis of CD44 in HeLa cells (positive; . Lane 2) and MOLT-4 cells (negative; . Lane 1) using anti-CD44 (IM7) purified; non-reducing conditions.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rat IgG2b |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
| Subcellular location: | Cell membrane, Cell projection |
| Post transnational modification: | Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
| Tissue Specificity: | Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. |
| BioGrid: | 107398. 132 interactions. |
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