Anti-CD44 Monoclonal Antibody (Clone:IM7)-PE Conjugated(Discontinued)

Product code: 30-2291

Clone name : IM7
Clonality : Monoclonal
Application : FACS, IP, WB, IHC, IHC-Fr, ICC
Reactivity : Human, Mouse, Dog, Equine, Feline
Conjugate : PE

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Amount : 0.1 mg
Isotype : Rat IgG2b
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD44
Gene ID : 960
Uniprot ID : P16070
Alternative Name : CD44, LHR, MDU2, MDU3, MIC4
Immunogen Information : Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Subcellular location: Cell membrane, Cell projection
Post transnational modification: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
Tissue Specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
BioGrid: 107398. 132 interactions.
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