Anti-CD43 / Leukosialin Monoclonal Antibody (Clone:MEM-59)-PE Conjugated
Figure 1: Surface staining of human peripheral blood with anti-CD43 (MEM-59) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
| Subcellular location: | Nucleus, Nucleus |
| Post transnational modification: | CD43 cytoplasmic tail: Sumoylated. |
| Tissue Specificity: | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| BioGrid: | 112571. 13 interactions. |
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