Anti-CD42b Monoclonal Antibody (Clone:AK2)-Low Endotoxin

Product code: 30-1588

Clone name : AK2
Clonality : Monoclonal
Application : FACS, IP, WB, ICC, ELISA
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : GP1BA
Gene ID : 2811
Uniprot ID : P07359
Alternative Name : GP1BA
Immunogen Information : Human platelets
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Subcellular location: Membrane
Post transnational modification: Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis.
BioGrid: 109073. 10 interactions.
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