Anti-CD42b / GPIb alpha Monoclonal Antibody (Clone:HIP1)

Product code: 30-1243

Clone name : HIP1
Clonality : Monoclonal
Application : FACS, IHC-Fr, Functional Assay
Reactivity : Human, Non-Human Primates

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : GP1BA
Gene ID : 2811
Uniprot ID : P07359
Alternative Name : GP1BA
Immunogen Information : Peripheral blood mononuclear cells of a patient suffering with CLL.
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.

Flow Cytometry Immunohistochemistry (frozen sections) Functional Application The antibody HIP1 inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets and ristocetin-induced platelet agglutination.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis.
BioGrid: 109073. 10 interactions.
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