Anti-CD358 / DR6 / TNFRSF21 Monoclonal Antibody (Clone:DR-6-04-EC)(Discontinued)

Product code: 30-1277

Clone name : DR-6-04-EC
Clonality : Monoclonal
Application : FACS, IP, ICC
Reactivity : Human

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TNFRSF21
Gene ID : 27242
Uniprot ID : O75509
Alternative Name : TNFRSF21, DR6, UNQ437/PRO868
Immunogen Information : A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked to the Fc portion of human IgG1 was used as an immunogen.
CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses.
Subcellular location: Cell membrane
Tissue Specificity: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
BioGrid: 118090. 9 interactions.
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