Anti-CD33 Monoclonal Antibody (Clone:WM53)-Low Endotoxin

Product code: 30-1644

Clone name : WM53
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD33
Gene ID : 945
Uniprot ID : P20138
Alternative Name : CD33, SIGLEC3
Immunogen Information : Human AML cells

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
Tissue Specificity: Monocytic/myeloid lineage cells.
BioGrid: 107383. 12 interactions.
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