Anti-CD33 antibody(DM77), Rabbit mAb
Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD33 protein, hFc-His tagged protein can bind Rabbit anti-CD33 monoclonal antibody (clone: DM77) in a linear range of 1-100 ng/ml.
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| Amount : | 100 µg |
| Purification : | Purified from cell culture supernatant by affinity chromatography |
| Content : | Not Sterile |
| Storage condition : | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
| Alternative Name : | CD33,SIGLEC3,gp67,SIGLEC-3 |
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
ELISA 1/5000-10000;FACS 1/100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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