Anti-CD324 / E-Cadherin Monoclonal Antibody (Clone:67A4)
Figure 1: Separation of MCF-7 cells stained using anti-human CD324 (67A4) purified antibody (GAM APC, red-filled) from MCF-7 cells stained using mouse IgG1 isotype control (MOPC-21) purified antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD324 / E-cadherin is an epithelial cell surface molecule, which provides calcium-dependent homophilic interactions with E-cadherin of another cell. These intaractions take part in morphogenetic programs controlling the maintenance of the structural and functional integrity of epithelia and affect invasive potential of epithelial neoplasms. CD324 / E-cadherin is implicated in cell growth and differentiation, cell recognition, and sorting during developmental morphogenesis, as well as in aggregation-dependent cell survival. CD324 / E-cadherin-mediated cell adhesion system is highly regulated from inside the cell by a number of intracellular signaling pathways.
Flow Cytometry Application note:Tested on cell lines CACO-2 and HT-29. In this case the recommended concentration is 5-10 µg/ml per 1 million cells/ml.
Immunoprecipitation Western Blotting Immunohistochemistry (frozen sections) Recommended dilution:4-8 µg/ml
Positive tissue:tonsil
Immunocytochemistry
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell junction, Cell membrane, Endosome, Golgi apparatus |
| Post transnational modification: | O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3. |
| Tissue Specificity: | Non-neural epithelial tissues. |
| BioGrid: | 107434. 631 interactions. |
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