Anti-CD32 / FcgammaRII Monoclonal Antibody (Clone:3D3)-PE Conjugated

Product code: 30-2371

Clone name : 3D3
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : FCGR2B
Gene ID : 2213
Uniprot ID : P31994
Alternative Name : FCGR2B, CD32, FCG2, IGFR2
Immunogen Information : purified glycosylated recombinant human FcgammaRIIa2
CD32 (FcgammaRII) is a low affinity receptor for aggregated IgG. It is strongly expressed on monocytes, granulocytes, myeloid and myeloblastic cell lines, and weakly on B cells, CD34+ bone marrow cells, and resting and activated platelets. After binding its ligand, CD32 induces IgG-mediated phagocytosis and oxidative burst in monocytes and neutrophils, whereas in B cells it mediates a negative signal. This polymorphic transmembrane glycoprotein is expressed not only in the activating (CD32a) and inhibitory isoform (CD32b), but also in individual variants with differing avidities for IgG subtypes (e.g. the CD32a131R and CD32a131H allotypes).
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Tissue Specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
BioGrid: 108507. 5 interactions.
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