Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody(Clone: 7.3)

Product code: 36-2281

Clone name : 7.3
Clonality : Monoclonal
Application : Functional Assay, IF, FACS
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $270.00 

  • $520.00 

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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : FCGR2A
Gene ID : 2212
Uniprot ID : P12318
Alternative Name : CD32A; Fc fragment of IgG low affinity IIa receptor; Fc gamma RIIa; Fc-gamma RII-a; Fc-gamma-RIIa; FCGR2A; FcgRII; Fcr-2; FcRII-a; IGFR2; IgG Fc receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-a; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17
Immunogen Information : K562 and FcgRII+L cells
This MAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Functional Studies (Order Ab without BSA & Azide)Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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