Anti-CD314 Monoclonal Antibody (Clone:1D11)

Product code: 30-1458

Clone name : 1D11
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : KLRK1
Gene ID : 22914
Uniprot ID : P26718
Alternative Name : KLRK1, D12S2489E, NKG2D
Immunogen Information : NKL cell line

CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.

Flow Cytometry Immunoprecipitation Immunohistochemistry (frozen sections) Functional Application blocking of ligand binding

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Tissue Specificity: Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
BioGrid: 116576. 2 interactions.
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