Low endotoxin, Anti-CD28 Monoclonal Antibody (Clone:CD28.2)

Product code: 30-1621

Clone name : CD28.2
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD28
Gene ID : 940
Uniprot ID : P10747
Alternative Name : CD28
Immunogen Information : DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA

CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Subcellular location: Cell surface
Post transnational modification: CD40LG induces tyrosine phosphorylation of isoform 3.
Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
BioGrid: 107378. 20 interactions.
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