Anti-CD273 / PD-L2 Monoclonal Antibody (Clone:24F.10C12)-PE Conjugated
Figure 1: Surface staining of CD273 on monocyte-derived dendritic cells with anti-CD273 (24F.10C12) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2a |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| BioGrid: | 123259. 12 interactions. |
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