Anti-CD271 / NGFR Monoclonal Antibody (Clone:NGFR5)-Biotin Conjugated
Figure 1: Surface staining (mass cytometry) of brain tumor cells with anti-CD271 (NGFR5) 143Nd. Gated on singlets.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
| Subcellular location: | Membrane |
| Post transnational modification: | Phosphorylated on serine residues. |
| BioGrid: | 110870. 37 interactions. |
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