Azide free, Anti-CD264 / TRAIL-R4 Monoclonal Antibody (Clone:TRAIL-R4-01)

Product code: 30-1024

Clone name : TRAIL-R4-01
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$433.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TNFRSF10D
Gene ID : 8793
Uniprot ID : Q9UBN6
Alternative Name : TNFRSF10D, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288
Immunogen Information : TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).

Flow Cytometry Recommended dilution:1-5 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Tissue Specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
BioGrid: 114321. 6 interactions.
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