Anti-CD264 / TRAIL-R4 Monoclonal Antibody (Clone:TRAIL-R4-01)-FITC Conjugated

Product code: 30-2025

Clone name : TRAIL-R4-01
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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0.1 mg
$512.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : TNFRSF10D
Gene ID : 8793
Uniprot ID : Q9UBN6
Alternative Name : TNFRSF10D, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288
Immunogen Information : TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Subcellular location: Membrane
Tissue Specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
BioGrid: 114321. 6 interactions.
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