PE Conjugated, Anti-CD263 / TRAIL-R3 Monoclonal Antibody (Clone:TRAIL-R3-02)

Product code: 30-2252

Clone name : TRAIL-R3-02
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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Size
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0.1 mg
$573.00 

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For estimated delivery dates, please contact us at [email protected]


Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : TNFRSF10C
Gene ID : 8794
Uniprot ID : O14798
Alternative Name : TNFRSF10C, DCR1, LIT, TRAILR3, TRID, UNQ321/PRO366
Immunogen Information : TRAIL-R3 (aa 1-280) - hIgGhc fusion protein

TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).

Subcellular location: Cell membrane
Post transnational modification: N-glycosylated and O-glycosylated.
Tissue Specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
BioGrid: 114322. 63 interactions.
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