Anti-CD261 / TRAIL-R1 / DR4 Monoclonal Antibody (Clone:DR-4-02)

Product code: 30-1276

Clone name : DR-4-02
Clonality : Monoclonal
Application : FACS, IP, ICC, Functional Assay
Reactivity : Human

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0.1 mg
$433.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TNFRSF10A
Gene ID : 8797
Uniprot ID : O00220
Alternative Name : TNFRSF10A, APO2, DR4, TRAILR1
Immunogen Information : Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Subcellular location: Membrane
Tissue Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
BioGrid: 114325. 50 interactions.
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