Anti-CD255 / TWEAK Monoclonal Antibody (Clone:CARL-1)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG3 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide |
| Immunogen Information : | human CD255-transfected 2PK-3 cells |
CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
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