Anti-CD253 / TRAIL Monoclonal Antibody (Clone:2E5)
Figure 1: Apoptosis induced in JURKAT human T cell leukemia cell line by soluble recombinant human TRAIL is completely blocked by anti-human TRAIL (2E5).The neutralizing activity of the antibody 2E5 has been confirmed with various sources of soluble recombinant human TRAIL.A - mediumB - recombinant TRAILC - recombinant TRAIL + anti-human TRAIL (2E5; 0.06 µg/ml)D - recombinant TRAIL + anti-human TRAIL (2E5; 0.24 µg/ml) E - recombinant TRAIL + Isotype mouse IgG1 control
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).
Functional Application The antibody 2E5 has high neutralizing activity for human TRAIL in biological assays. Flow Cytometry Recommended dilution:1-10 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Secreted |
| Post transnational modification: | Tyrosine phosphorylated by PKDCC/VLK. |
| Tissue Specificity: | Widespread; most predominant in spleen, lung and prostate. |
| BioGrid: | 114280. 20 interactions. |
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