Anti-CD253 / TRAIL Monoclonal Antibody (Clone:2E5)

Figure 1: Induction of apoptosis Figure 1: Apoptosis induced in JURKAT human T cell leukemia cell line by soluble recombinant human TRAIL is completely blocked by anti-human TRAIL (2E5).The neutralizing activity of the antibody 2E5 has been confirmed with various sources of soluble recombinant human TRAIL.A - mediumB - recombinant TRAILC - recombinant TRAIL + anti-human TRAIL (2E5; 0.06 µg/ml)D - recombinant TRAIL + anti-human TRAIL (2E5; 0.24 µg/ml) E - recombinant TRAIL + Isotype mouse IgG1 control

Anti-CD253 / TRAIL Monoclonal Antibody (Clone:2E5)

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Product code: 30-1605

Clone name :	2 E 5
Clonality :	Monoclonal
Application :	Functional Assay
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	0.1 mg
Isotype :	Mouse IgG1
Purification :	Purified by protein-A affinity chromatography
Storage condition :	Store at 2-8°C. Do not freeze.


Gene :	TNFSF10
Gene ID :	8743
Uniprot ID :	P50591
Alternative Name :	TNFSF10, APO2L, TRAIL
Immunogen Information :	Recombinant soluble fragment (aa 95-281) of human TRAIL.

Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).

Functional Application The antibody 2E5 has high neutralizing activity for human TRAIL in biological assays. Flow Cytometry Recommended dilution:1-10 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane, Secreted
Post transnational modification:	Tyrosine phosphorylated by PKDCC/VLK.
Tissue Specificity:	Widespread; most predominant in spleen, lung and prostate.
BioGrid:	114280. 20 interactions.