Anti-CD253 / TRAIL Monoclonal Antibody (Clone:2E5)

Product code: 30-1605

Clone name : 2 E 5
Clonality : Monoclonal
Application : Functional Assay
Reactivity : Human

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0.1 mg
$433.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TNFSF10
Gene ID : 8743
Uniprot ID : P50591
Alternative Name : TNFSF10, APO2L, TRAIL
Immunogen Information : Recombinant soluble fragment (aa 95-281) of human TRAIL.

Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).

Functional Application The antibody 2E5 has high neutralizing activity for human TRAIL in biological assays. Flow Cytometry Recommended dilution:1-10 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Secreted
Post transnational modification: Tyrosine phosphorylated by PKDCC/VLK.
Tissue Specificity: Widespread; most predominant in spleen, lung and prostate.
BioGrid: 114280. 20 interactions.
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