Anti-CD243 / MDR-1 Monoclonal Antibody (Clone:UIC2)-Low Endotoxin

Product code: 30-1661

Clone name : UIC2
Clonality : Monoclonal
Application : FACS, IP, IHC, IHC-Fr, Functional Assay
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ABCB1
Gene ID : 5243
Uniprot ID : P08183
Alternative Name : ABCB1, MDR1, PGY1
Immunogen Information : NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).

Flow Cytometry Immunoprecipitation Immunohistochemistry Application note: heat mediated antigen retrieval in citrate buffer pH 6
Immunohistochemistry (frozen sections) Functional Application inhibition

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Tissue Specificity: Expressed in liver, kidney, small intestine and brain.
BioGrid: 111262. 17 interactions.
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