Anti-CD24 Monoclonal Antibody (Clone:SN3)-PE Conjugated

Product code: 30-2247

Clone name : SN3
Clonality : Monoclonal
Application : FACS, IHC-Fr
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD24
Gene ID : 100133941
Uniprot ID : P25063
Alternative Name : CD24, CD24A
Immunogen Information : Glycoproteins purified from human NALM-1 cell line.
CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
Subcellular location: Cell membrane
Post transnational modification: Extensively O-glycosylated.
Tissue Specificity: B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
BioGrid: 107372. 4 interactions.
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