Anti-CD230 / Human Prion Protein (PrP) Monoclonal Antibody (Clone:EM-20)
Figure 1: Western blotting analysis of Creutzfeld-Jakob disease (CJD) negative (. Lane 2) and CJD positive (. Lane 3, 4) human brain material using anti-PrP antibody (clone EM-20). CJD positive patient has proteinase K resistent prion protein. Lane 4: Samples with proteinase K treatment . Lane 2, 3: Samples without proteinase K treatment
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2a |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD230 / Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. CD230 / PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
Western Blotting Recommended dilution: 0.5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Isoform 2 is sumoylated with SUMO1. |
| BioGrid: | 111606. 72 interactions. |
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