Anti-CD23 Monoclonal Antibody (Clone:EBVCS-5)(Discontinued)

Product code: 30-1491

Clone name : EBVCS-5
Clonality : Monoclonal
Application : FACS, IP
Reactivity : Human

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : FCER2
Gene ID : 2208
Uniprot ID : P06734
Alternative Name : FCER2, CD23A, CLEC4J, FCE2, IGEBF
Immunogen Information : EBV-transformed human cells
CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.
Subcellular location: Cell membrane, Cell membrane, Secreted
Post transnational modification: The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
BioGrid: 108502. 4 interactions.
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