Anti-CD229 / Ly9 Monoclonal Antibody (Clone:HLy9.25)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD229 (Ly9) is a cell surface receptor of the CD150 family, which includes also e.g. CD48 and CD224. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. High levels of CD229 are found on T and B cells, where its expression increases during their maturation. It is absent on granulocytes, bone marrow-derived dendritic cells, platelets and erythrocytes. CD229 has been also reported on mouse monocytes and NK cells. CD229 interacts homophilically through its N-terminal domain and localizes to the contact site between T cells and antigen presenting B cells during antigen-dependent immune synapse formation.
Flow Cytometry Recommended dilution:6 µg/ml
Positive control:peripheral blood lymphocytes
Immunoprecipitation Western Blotting Immunocytochemistry Functional Application Regulation of activation
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane, Cell membrane |
| Tissue Specificity: | Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. |
| BioGrid: | 110241. 4 interactions. |
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