Anti-CD229 / Ly9 Monoclonal Antibody (Clone:HLy9.25)-PE Conjugated
Figure 1: Surface staining of human peripheral blood cells with anti-human CD229 (HLy9.25) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD229 (Ly9) is a cell surface receptor of the CD150 family, which includes also e.g. CD48 and CD224. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. High levels of CD229 are found on T and B cells, where its expression increases during their maturation. It is absent on granulocytes, bone marrow-derived dendritic cells, platelets and erythrocytes. CD229 has been also reported on mouse monocytes and NK cells. CD229 interacts homophilically through its N-terminal domain and localizes to the contact site between T cells and antigen presenting B cells during antigen-dependent immune synapse formation.
| Subcellular location: | Membrane, Cell membrane |
| Tissue Specificity: | Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. |
| BioGrid: | 110241. 4 interactions. |
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