Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)(Discontinued)

Product code: 30-1089

Clone name : S-HCL-1
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD22
Gene ID : 933
Uniprot ID : P20273
Alternative Name : CD22, SIGLEC2
Immunogen Information : Whole hairy cell leukemia cells and membrane preparation
CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated on tyrosine residues by LYN.
Tissue Specificity: B-lymphocytes.
BioGrid: 107371. 15 interactions.
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