Anti-CD207 Monoclonal Antibody (Clone:2G3)
Figure 1: Flow cytometry intracellular staining pattern of human stimulated (GM-CSF + IL-4 + TGF-beta) peripheral blood mononuclear cells whole blood stained using anti-human CD207 (2G3) purified antibody (concentration in sample 0.56 μg/ml, GAM APC).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 lambda |
| Purification : | Purified by protein-A affinity chromatography. |
| Content : | Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.
flow cytometry: Recommended dilution: 0.5-4 μg/ml. Extracellular and intracellular staining.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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