Anti-CD203c Monoclonal Antibody (Clone:NP4D6)-PE Conjugated
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.
| Subcellular location: | Cell membrane, Apical cell membrane, Secreted |
| Post transnational modification: | N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. |
| Tissue Specificity: | Detected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822). Detected in prostate and uterus (PubMed:9344668). Detected on basophils, but not neutrophils (PubMed:11342463). |
| BioGrid: | 111195. 1 interactions. |
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