Anti-CD200 Monoclonal Antibody (Clone:OX-104)-PE Conjugated
Figure 1: Surface staining of CD200 in human peripheral blood with anti-CD200 (OX-104) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization.
| Subcellular location: | Cell membrane |
| Post transnational modification: | The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform. |
| Tissue Specificity: | Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells. |
| BioGrid: | 126281. 8 interactions. |
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